What is 'chance'?
A random event or something that occurs without without any obvious intention or cause
Can chance create anything?
"Chance" itself is an abstract notion. Can chemicals come into contact randomly by chance to form another chemical? Sure. Happens all the time
Has chance ever created anything?
Abstract notions don't work that way
What is a design?
The art or action of conceiving or producing a plan usually BEFORE it's made/produced/assembled
Do the simplest forms of life lack a design?
We'll, dog breeders have a hand in how their results will turn out as an example of design input from a third party when it comes to a biological example, but I'd need more information. Can you be more specific here?
How could a protocell replicate itself if it had no design?
Something does not require a design process to reproduce. For example, there's bacteria in existence that only feeds exclusively on nylon. As nylon did not exist before the 1930's neither did this strain of bacteria.
However, it's postulated that a pre-existing bacteria adapted to its surroundings where only nylon was present to feed on. Now it cannot survive without it.
What conclusion does this evidence point to?
Well, it's evidence of the evolution of a species over time to be sure, but it also suggests that these "non-designed" bacteria can happily reprodce without a design process.
This species did not exist. An extant species found itself in an environment it had to adapt to in order to survive. It adapted. It multiplied. It flourished.
No 3rd party in the capacity of a designer required.